PS128 (L. plantarum)
Clinical: Neurodevelopment
Randomized Controlled Trial of Probiotic PS128 in Children with Tourette Syndrome
Lactobacillus plantarum PS128 and Other Probiotics in Children and Adolescents with Autism Spectrum Disorder: A Real-World Experience
Benefits for measures of autism
Benefits for measures of autism
Benefits for measures of autism and ADHD
Clinical: Neurodegeneration
The Add-On Effect of Lactobacillus plantarum PS128 in Patients with Parkinson's Disease: A Pilot Study
Clinical: Mental Health
Clinical Application Value of Lactobacillus Plantarum PS128 in Patients with Anxiety Disorders
Insomnia and depression symptom benefits
Insomnia, anxiety, and stress symptom benefits
Clinical: Physical Fitness
Lactobacillus plantarum PS128 Improves Physiological Adaptation and Performance in Triathletes through Gut Microbiota Modulation
Endurance and gut microbiota benefits
Endurance and recovery benefits
Preclinical: Neural Function
Alzheimer's-like symptom benefits
Lactobacillus plantarum PS128 ameliorates 2,5-Dimethoxy-4-iodoamphetamine-induced tic-like behaviors via its influences on the microbiota-gut-brain-axis
Tourette-like symptom benefits; dopamine level improvements
Parkinson's-like symptom benefits
Parkinson’s-like symptom benefits; dopamine and BDNF level improvements
Anxiety-like symptom benefits; dopamine and serotonin level improvements
Psychotropic effects of Lactobacillus plantarum PS128 in early life-stressed and naïve adult mice
Depression- and anxiety-like symptom benefits; dopamine and serotonin level improvements
Preclinical: GI and Immune Function
Lactobacillus plantarum PS128 Ameliorated Visceral Hypersensitivity in Rats Through the Gut-Brain Axis
Gastrointestinal symptom benefits
Lactobacillus plantarum PS128 Promotes Intestinal Motility, Mucin Production, and Serotonin Signaling in Mice
Gastrointestinal and immune benefits
Safety
Toxicity Studies of Lactobacillus plantarum PS128™ Isolated from Spontaneously Fermented Mustard Greens
PS23 (L. paracasei)
Clinical: Muscle Health
Live and Heat-Killed Probiotic Lactobacillus paracasei PS23 Accelerated the Improvement and Recovery of Strength and Damage Biomarkers after Exercise-Induced Muscle Damage
Muscle strength and accelerated recovery benefits after muscle damage
Effectiveness of a Novel Food Composed of Leucine, Omega-3 Fatty Acids and Probiotic Lactobacillus paracasei PS23 for the Treatment of Sarcopenia in Elderly Subjects: A 2-Month Randomized Double-Blind Placebo-Controlled Trial
Body composition, strength and movement benefits for sarcopenia
Clinical: Mental Health
Psychobiotic Supplementation of HK-PS23 Improves Anxiety in Highly Stressed Clinical Nurses: A Double-Blind Randomized Placebo-Controlled Study
Anxiety symptom benefits; cortisol (stress hormone) level improvements
Preclinical: Aging Effects
Cognitive and anxiety-like symptom benefits
Lactobacillus paracasei PS23 Effectively Modulates Gut Microbiota Composition and Improves Gastrointestinal Function in Aged SAMP8 Mice
Cognitive, gastrointestinal function, and gut microbiota benefits
Lactobacillus paracasei PS23 dietary supplementation alleviates muscle aging via ghrelin stimulation in d-galactose-induced aging mice
Muscle atrophy benefits
Lactobacillus paracasei PS23 decelerated age-related muscle loss by ensuring mitochondrial function in SAMP8 mice
Muscle mass, strength, and mitochondria function benefits
Preclinical: Mental Health
Depression- and anxiety-like symptom benefits; stress hormone and dopamine level improvements
Antidepressant-like activities of live and heat-killed Lactobacillus paracasei PS23 in chronic corticosterone-treated mice and possible mechanisms
Depression-like symptom benefits; serotonin, dopamine, and BDNF level improvements
Preclinical: GI Function
Lactobacillus paracasei PS23 Effectively Modulates Gut Microbiota Composition and Improves Gastrointestinal Function in Aged SAMP8 Mice
Gastrointestinal and gut microbiota benefits
PS150 (L. fermentum)
Preclinical: Sleep
PS150 promotes non-rapid eye movement sleep in the first night effect of mice
Sleep benefits; stress hormone level improvements
Hypnotic Effects of Lactobacillus fermentum PS150TM on Pentobarbital-Induced Sleep in Mice
Preclinical: Neural Function
Lactobacillus fermentum PS150 showed psychotropic properties by altering serotonergic pathway during stress
Memory and cognition benefits; serotonin level improvements
Molecular evolutionary and 3D protein structural analyses of Lactobacillus fermentum elongation factor Tu, a novel brain health promoting factor
Other Strains (K21, A17 and K37)
Preclinical: Digestive Metabolism
Effect of Lactobacillus plantarum Strain K21 on High-Fat Diet-Fed Obese Mice
Gut barrier benefits; cholesterol and triglyceride level improvements
Preclinical: Immune Function
Immunomodulatory Activity of Lactococcus lactis A17 from Taiwan Fermented Cabbage in OVA-Sensitized BALB/c Mice
Allergy symptom and prevention benefits
Oral administration of heat-inactivated Lactobacillus plantarum K37 modulated airway hyperresponsiveness in ovalbumin-sensitized BALB/c mice