雜誌的堆棧

Published Research

By strain:  PS128    PS23    PS150    K21    A17    K37

PS128 (L. plantarum)

Clinical: Neurodevelopment

Randomized Controlled Trial of Probiotic PS128 in Children with Tourette Syndrome

Benefits for measures of ADHD 

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Lactobacillus plantarum PS128 and Other Probiotics in Children and Adolescents with Autism Spectrum Disorder: A Real-World Experience

Benefits for measures of autism

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Probiotic and Oxytocin Combination Therapy in Patients with Autism Spectrum Disorder: A Randomized, Double-Blinded, Placebo-Controlled Pilot Trial

Benefits for measures of autism

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Effects of Lactobacillus plantarum PS128 on Children with Autism Spectrum Disorder in Taiwan: A Randomized, Double-Blind, Placebo-Controlled Trial

Benefits for measures of autism and ADHD

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Clinical: Neurodegeneration

The Add-On Effect of Lactobacillus plantarum PS128 in Patients with Parkinson's Disease: A Pilot Study 

Parkinson's symptom benefits

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Clinical: Mental Health

Psychophysiological Effects of Lactobacillus plantarum PS128 in Patients with Major Depressive Disorder: A Preliminary 8-Week Open Trial

Depression symptom benefits

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Effects of Lactobacillus plantarum PS128 on Depressive Symptoms and Sleep Quality in Self-Reported Insomniacs: A Randomized, Double-Blind, Placebo-Controlled Pilot Trial

Insomnia and depression symptom benefits

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Psychobiotic Supplementation of PS128 Improves Stress, Anxiety, and Insomnia in Highly Stressed Information Technology Specialists: A Pilot Study

Insomnia, anxiety, and stress symptom benefits

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Clinical: Physical Fitness

Effect of Daily Oral Lactobacillus plantarum PS128 on Exercise Capacity Recovery after a Half-Marathon

Speed and strength benefits

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Lactobacillus plantarum PS128 Improves Physiological Adaptation and Performance in Triathletes through Gut Microbiota Modulation

Endurance and gut microbiota benefits

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The Beneficial Effects of Lactobacillus plantarum PS128 on High-Intensity, Exercise-Induced Oxidative Stress, Inflammation, and Performance in Triathletes

Endurance and recovery benefits

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Preclinical: Neural Function

Lactobacillus plantarum PS128 prevents cognitive dysfunction in Alzheimer's disease mice by modulating propionic acid levels, glycogen synthase kinase 3 beta activity, and gliosis

Alzheimer's-like symptom benefits

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Lactobacillus plantarum PS128 ameliorates 2,5-Dimethoxy-4-iodoamphetamine-induced tic-like behaviors via its influences on the microbiota-gut-brain-axis

Tourette-like symptom benefits; dopamine level improvements

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Lactiplantibacillus plantarum PS128 Alleviates Exaggerated  Cortical Beta Oscillations and Motor Deficits in the 6-Hydroxydopamine Rat Model of Parkinson's Disease

Parkinson's-like symptom benefits

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Lactobacillus plantarum PS128 alleviates neurodegenerative progression in 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine-induced mouse models of Parkinson's disease

Parkinson’s-like symptom benefits; dopamine and BDNF level improvements

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Alteration of behavior and monoamine levels attributable to Lactobacillus plantarum PS128 in germ-free mice

Anxiety-like symptom benefits; dopamine and serotonin level improvements

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Psychotropic effects of Lactobacillus plantarum PS128 in early life-stressed and naïve adult mice

Depression- and anxiety-like symptom benefits; dopamine and serotonin level improvements

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Preclinical: GI and Immune Function

Lactobacillus plantarum PS128 Ameliorated Visceral Hypersensitivity in Rats Through the Gut-Brain Axis

Gastrointestinal symptom benefits

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Lactobacillus plantarum PS128 Promotes Intestinal Motility, Mucin Production, and Serotonin Signaling in Mice

Gastrointestinal and immune benefits

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Safety

Toxicity Studies of Lactobacillus plantarum PS128™ Isolated from Spontaneously Fermented Mustard Greens

PS23 (L. paracasei)

Clinical: Mental Health

Psychobiotic Supplementation of HK-PS23 Improves Anxiety in Highly Stressed Clinical Nurses: A Double-Blind Randomized Placebo-Controlled Study

Anxiety symptom benefits; cortisol (stress hormone) level improvements

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Preclinical: Aging Effects

Lactobacillus paracasei PS23 improves cognitive deficits via modulating the hippocampal gene expression and the gut microbiota in D-galactose-induced aging mice

Memory and movement benefits

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Lactobacillus paracasei PS23 Delays Progression of Age-Related Cognitive Decline in Senescence Accelerated Mouse Prone 8 (SAMP8) Mice

Cognitive and anxiety-like symptom benefits

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Lactobacillus paracasei PS23 Effectively Modulates Gut Microbiota Composition and Improves Gastrointestinal Function in Aged SAMP8 Mice

Cognitive, gastrointestinal function, and gut microbiota benefits

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Lactobacillus paracasei  PS23 dietary supplementation alleviates muscle aging via ghrelin stimulation in d-galactose-induced aging mice

Muscle atrophy benefits

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Lactobacillus paracasei  PS23 decelerated age-related muscle loss by ensuring mitochondrial function in SAMP8 mice

Muscle mass, strength, and mitochondria function benefits

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Preclinical: Mental Health

Lactobacillus paracasei PS23 reduced early-life stress abnormalities in maternal separation mouse model

Depression- and anxiety-like symptom benefits; stress hormone and dopamine level improvements

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Antidepressant-like activities of live and heat-killed Lactobacillus paracasei PS23 in chronic corticosterone-treated mice and possible mechanisms

Depression-like symptom benefits; serotonin, dopamine, and BDNF level improvements

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Preclinical: GI Function

Lactobacillus paracasei PS23 Effectively Modulates Gut Microbiota Composition and Improves Gastrointestinal Function in Aged SAMP8 Mice

Gastrointestinal and gut microbiota benefits

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Coculture Strategy for Developing Lactobacillus paracasei PS23 Fermented Milk with Anti-Colitis Effect

Gut barrier and anti-colitis benefits