Published Research
Listed by probiotic strain
L. plantarum PS128
Clinical Studies
Neurodevelopment
1. Randomized Controlled Trial of Probiotic PS128 in Children with Tourette Syndrome
ADHD symptoms significantly decreased in children with Tourette syndrome taking PS128
2. Lactobacillus plantarum PS128 and Other Probiotics in Children and Adolescents with Autism Spectrum Disorder: A Real-World Experience
Significant improvements in autism patients taking PS128, more than other probiotics
3. Probiotic and Oxytocin Combination Therapy in Patients with Autism Spectrum Disorder: A Randomized, Double-Blinded, Placebo-Controlled Pilot Trial
Overall improvement in autism patients from PS128 and oxytocin combination therapy
Alleviated ADHD and other symptoms of autism in children
Neurodegeneration
1. The Add-On Effect of Lactobacillus plantarum PS128 in Patients with Parkinson's Disease: A Pilot Study
Improved motor function and quality of life in Parkinson's patients taking levodopa
Mental Health
Depressive thoughts, feelings, and other symptoms significantly decreased
Improved depressive symptoms and sleep quality
Benefited anxiety, stress, and insomnia in highly-stressed office workers
Exercise Performance
Faster split times and increased lower leg strength in recreational runners
2. Lactobacillus plantarum PS128 Improves Physiological Adaptation and Performance in Triathletes through Gut Microbiota Modulation
Benefits to exercise recovery and athletic performance in athletes
3. The Beneficial Effects of Lactobacillus plantarum PS128 on High-Intensity, Exercise-Induced Oxidative Stress, Inflammation, and Performance in Triathletes
Benefited oxidative stress, exercise performance, and serum BCAA levels in athletes
Preclinical Studies
Lactobacillus plantarum PS128 ameliorates 2,5-Dimethoxy-4-iodoamphetamine-induced tic-like behaviors via its influences on the microbiota-gut-brain-axis
Regulated dopamine and reduced Tourette syndrome-like behavior
PS128 comparable to, lasted longer than levodopa, DBS in improving Parkinson's indicators
Enhanced dopamine and BDNF, reduced Parkinson’s disease-like symptoms
Regulated dopamine and serotonin levels, improved anxiety-like behaviors
Psychotropic effects of Lactobacillus plantarum PS128 in early life-stressed and naïve adult mice
Lowered anxiety- and depression-like behaviors, regulated related dopamine and serotonin
Digestive and Immune Function
Lactobacillus plantarum PS128 Ameliorated Visceral Hypersensitivity in Rats Through the Gut-Brain Axis
Ameliorated gastrointestinal symptoms
Lactobacillus plantarum PS128 Promotes Intestinal Motility, Mucin Production, and Serotonin Signaling in Mice
Increased digestive activity and immune protection
Safety
Toxicity Studies of Lactobacillus plantarum PS128™ Isolated from Spontaneously Fermented Mustard Greens
L. paracasei PS23
Preclinical Studies
Aging (Muscle and Brain)
Lactobacillus paracasei PS23 dietary supplementation alleviates muscle aging via ghrelin stimulation in d-galactose-induced aging mice
Alleviated muscle atrophy that resulted from aging
Lactobacillus paracasei PS23 decelerated age-related muscle loss by ensuring mitochondrial function in SAMP8 mice
Ameliorated age-related loss of mitochondrial function, muscle mass, and strength
Lactobacillus paracasei PS23 Delays Progression of Age-Related Cognitive Decline in Senescence Accelerated Mouse Prone 8 (SAMP8) Mice
Lessened cognitive, behavioral, and physiological signs of aging
Lactobacillus paracasei PS23 Effectively Modulates Gut Microbiota Composition and Improves Gastrointestinal Function in Aged SAMP8 Mice
Improved gut microbiota composition and GI function related to cognitive and muscle loss
Mental Health
Diminished anxiety- and depression-like symptoms, stress hormones, and inflammation
Antidepressant-like activities of live and heat-killed Lactobacillus paracasei PS23 in chronic corticosterone-treated mice and possible mechanisms
Raised BDNF levels, reduced depression- and anxiety-like behaviors and stress hormone
Digestive Health
Lactobacillus paracasei PS23 Effectively Modulates Gut Microbiota Composition and Improves Gastrointestinal Function in Aged SAMP8 Mice
Improved gut microbiota composition and GI function
Strengthened intestinal epithelial barrier and showed anti-colitis benefits
L. fermentum PS150
Preclinical Studies
Sleep and Brain Health
Lactobacillus fermentum PS150 promotes non-rapid eye movement sleep in the first night effect of mice
Improved sleep quality and reduced stress hormone
Lactobacillus fermentum PS150 showed psychotropic properties by altering serotonergic pathway during stress
Maintained serotonin levels, cognition, and memory
Hypnotic Effects of Lactobacillus fermentum PS150TM on Pentobarbital-Induced Sleep in Mice
Decreased sleep latency and increased sleep duration even more than diphenhydramine
Molecular evolutionary and 3D protein structural analyses of Lactobacillus fermentum elongation factor Tu, a novel brain health promoting factor
Other Strains A17, K37, K21
Preclinical Studies
Digestive Metabolism
Effect of Lactobacillus plantarum Strain K21 on High-Fat Diet-Fed Obese Mice
Lowered body weight and regulated lipid markers
Immunity
Immunomodulatory Activity of Lactococcus lactis A17 from Taiwan Fermented Cabbage in OVA-Sensitized BALB/c Mice
Oral administration of heat-inactivated Lactobacillus plantarum K37 modulated airway hyperresponsiveness in ovalbumin-sensitized BALB/c mice