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Published Research

 Listed by strains:  PS128    PS23    PS150    K21    A17    K37

PS128 (L. plantarum)

Clinical: Neurodevelopment

Randomized Controlled Trial of Probiotic PS128 in Children with Tourette Syndrome

Improvements in ADHD 

Lactobacillus plantarum PS128 and Other Probiotics in Children and Adolescents with Autism Spectrum Disorder: A Real-World Experience

Improvements in autism

Probiotic and Oxytocin Combination Therapy in Patients with Autism Spectrum Disorder: A Randomized, Double-Blinded, Placebo-Controlled Pilot Trial

Improvements in autism

Effects of Lactobacillus plantarum PS128 on Children with Autism Spectrum Disorder in Taiwan: A Randomized, Double-Blind, Placebo-Controlled Trial

Improvements in autism and ADHD

Clinical: Neurodegeneration

The Add-On Effect of Lactobacillus plantarum PS128 in Patients with Parkinson's Disease: A Pilot Study 

Parkinson's symptom benefits

Clinical: Mental Health

Clinical Application Value of Lactobacillus Plantarum PS128 in Patients with Anxiety Disorders

Anxiety symptom benefits

Psychophysiological Effects of Lactobacillus plantarum PS128 in Patients with Major Depressive Disorder: A Preliminary 8-Week Open Trial

Depression symptom benefits

Effects of Lactobacillus plantarum PS128 on Depressive Symptoms and Sleep Quality in Self-Reported Insomniacs: A Randomized, Double-Blind, Placebo-Controlled Pilot Trial

Insomnia and depression symptom benefits

Psychobiotic Supplementation of PS128 Improves Stress, Anxiety, and Insomnia in Highly Stressed Information Technology Specialists: A Pilot Study

Insomnia, anxiety, and stress symptom benefits

Clinical: Physical Fitness

Effect of Daily Oral Lactobacillus plantarum PS128 on Exercise Capacity Recovery after a Half-Marathon

Speed and strength benefits

Lactobacillus plantarum PS128 Improves Physiological Adaptation and Performance in Triathletes through Gut Microbiota Modulation

Endurance and gut microbiota benefits

The Beneficial Effects of Lactobacillus plantarum PS128 on High-Intensity, Exercise-Induced Oxidative Stress, Inflammation, and Performance in Triathletes

Endurance and recovery benefits

Preclinical: Neural Function

Lactobacillus plantarum PS128 prevents cognitive dysfunction in Alzheimer's disease mice by modulating propionic acid levels, glycogen synthase kinase 3 beta activity, and gliosis

Alzheimer's-like symptom benefits

Lactobacillus plantarum PS128 ameliorates 2,5-Dimethoxy-4-iodoamphetamine-induced tic-like behaviors via its influences on the microbiota-gut-brain-axis

Tourette-like symptom benefits; dopamine level improvements

Lactiplantibacillus plantarum PS128 Alleviates Exaggerated  Cortical Beta Oscillations and Motor Deficits in the 6-Hydroxydopamine Rat Model of Parkinson's Disease

Parkinson's-like symptom benefits

Lactobacillus plantarum PS128 alleviates neurodegenerative progression in 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine-induced mouse models of Parkinson's disease

Parkinson’s-like symptom benefits; dopamine and BDNF level improvements

Alteration of behavior and monoamine levels attributable to Lactobacillus plantarum PS128 in germ-free mice

Anxiety-like symptom benefits; dopamine and serotonin level improvements

Psychotropic effects of Lactobacillus plantarum PS128 in early life-stressed and naïve adult mice

Depression- and anxiety-like symptom benefits; dopamine and serotonin level improvements

Preclinical: GI and Immune Function

Lactobacillus plantarum PS128 Ameliorated Visceral Hypersensitivity in Rats Through the Gut-Brain Axis

Gastrointestinal symptom benefits

Lactobacillus plantarum PS128 Promotes Intestinal Motility, Mucin Production, and Serotonin Signaling in Mice

Gastrointestinal and immune benefits


Toxicity Studies of Lactobacillus plantarum PS128™ Isolated from Spontaneously Fermented Mustard Greens

PS23/HT-PS23 (L. paracasei)

Clinical: Muscle Health

Live and Heat-Killed Probiotic Lactobacillus paracasei PS23 Accelerated the Improvement and Recovery of Strength and Damage Biomarkers after Exercise-Induced Muscle Damage

Muscle strength and accelerated recovery benefits after muscle damage

Effectiveness of a Novel Food Composed of Leucine, Omega-3 Fatty Acids and Probiotic Lactobacillus paracasei PS23 for the Treatment of Sarcopenia in Elderly Subjects: A 2-Month Randomized Double-Blind Placebo-Controlled Trial

Body composition, strength and movement benefits for sarcopenia

Clinical: Mental Health

Psychobiotic Supplementation of HK-PS23 Improves Anxiety in Highly Stressed Clinical Nurses: A Double-Blind Randomized Placebo-Controlled Study

Anxiety symptom benefits; cortisol (stress hormone) level improvements

Preclinical: Aging Effects

Lactobacillus paracasei PS23 improves cognitive deficits via modulating the hippocampal gene expression and the gut microbiota in D-galactose-induced aging mice

Memory and movement benefits

Lactobacillus paracasei PS23 Delays Progression of Age-Related Cognitive Decline in Senescence Accelerated Mouse Prone 8 (SAMP8) Mice

Cognitive and anxiety-like symptom benefits

Lactobacillus paracasei PS23 Effectively Modulates Gut Microbiota Composition and Improves Gastrointestinal Function in Aged SAMP8 Mice

Cognitive, gastrointestinal function, and gut microbiota benefits

Lactobacillus paracasei  PS23 dietary supplementation alleviates muscle aging via ghrelin stimulation in d-galactose-induced aging mice

Muscle atrophy benefits

Lactobacillus paracasei  PS23 decelerated age-related muscle loss by ensuring mitochondrial function in SAMP8 mice

Muscle mass, strength, and mitochondria function benefits

Preclinical: Mental Health

Lactobacillus paracasei PS23 reduced early-life stress abnormalities in maternal separation mouse model

Depression- and anxiety-like symptom benefits; stress hormone and dopamine level improvements

Antidepressant-like activities of live and heat-killed Lactobacillus paracasei PS23 in chronic corticosterone-treated mice and possible mechanisms

Depression-like symptom benefits; serotonin, dopamine, and BDNF level improvements

Preclinical: GI Function

Lactobacillus paracasei PS23 Effectively Modulates Gut Microbiota Composition and Improves Gastrointestinal Function in Aged SAMP8 Mice

Gastrointestinal and gut microbiota benefits

Coculture Strategy for Developing Lactobacillus paracasei PS23 Fermented Milk with Anti-Colitis Effect

Gut barrier and anti-colitis benefits

Other Strains
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