雜誌的堆棧

Published Research

Listed by probiotic strain

L. plantarum PS128

Clinical Studies

Neurodevelopment

1. Randomized Controlled Trial of Probiotic PS128 in Children with Tourette Syndrome

ADHD symptoms significantly decreased in children with Tourette syndrome taking PS128 

2. Lactobacillus plantarum PS128 and Other Probiotics in Children and Adolescents with Autism Spectrum Disorder: A Real-World Experience

Significant improvements in autism patients taking PS128, more than other probiotics

3. Probiotic and Oxytocin Combination Therapy in Patients with Autism Spectrum Disorder: A Randomized, Double-Blinded, Placebo-Controlled Pilot Trial

Overall improvement in autism patients from PS128 and oxytocin combination therapy

4. Effects of Lactobacillus plantarum PS128 on Children with Autism Spectrum Disorder in Taiwan: A Randomized, Double-Blind, Placebo-Controlled Trial

Alleviated ADHD and other symptoms of autism in children

Neurodegeneration

1. The Add-On Effect of Lactobacillus plantarum PS128 in Patients with Parkinson's Disease: A Pilot Study 

Improved motor function and quality of life in Parkinson's patients taking levodopa

Mental Health

1. Psychophysiological Effects of Lactobacillus plantarum PS128 in Patients with Major Depressive Disorder: A Preliminary 8-Week Open Trial

Depressive thoughts, feelings, and other symptoms significantly decreased

2. Effects of Lactobacillus plantarum PS128 on Depressive Symptoms and Sleep Quality in Self-Reported Insomniacs: A Randomized, Double-Blind, Placebo-Controlled Pilot Trial

Improved depressive symptoms and sleep quality

3. Psychobiotic Supplementation of PS128 Improves Stress, Anxiety, and Insomnia in Highly Stressed Information Technology Specialists: A Pilot Study

Benefited anxiety, stress, and insomnia in highly-stressed office workers

Exercise Performance

1. Effect of Daily Oral Lactobacillus plantarum PS128 on Exercise Capacity Recovery after a Half-Marathon

Faster split times and increased lower leg strength in recreational runners

2. Lactobacillus plantarum PS128 Improves Physiological Adaptation and Performance in Triathletes through Gut Microbiota Modulation

Benefits to exercise recovery and athletic performance in athletes

3. The Beneficial Effects of Lactobacillus plantarum PS128 on High-Intensity, Exercise-Induced Oxidative Stress, Inflammation, and Performance in Triathletes

Benefited oxidative stress, exercise performance, and serum BCAA levels in athletes

Preclinical Studies

Neurological Function

Lactobacillus plantarum PS128 ameliorates 2,5-Dimethoxy-4-iodoamphetamine-induced tic-like behaviors via its influences on the microbiota-gut-brain-axis

Regulated dopamine and reduced Tourette syndrome-like behavior

Lactiplantibacillus plantarum PS128 Alleviates Exaggerated  Cortical Beta Oscillations and Motor Deficits in the 6-Hydroxydopamine Rat Model of Parkinson's Disease

PS128 comparable to, lasted longer than levodopa, DBS in improving Parkinson's indicators

Lactobacillus plantarum PS128 alleviates neurodegenerative progression in 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine-induced mouse models of Parkinson's disease

Enhanced dopamine and BDNF, reduced Parkinson’s disease-like symptoms

Alteration of behavior and monoamine levels attributable to Lactobacillus plantarum PS128 in germ-free mice

Regulated dopamine and serotonin levels, improved anxiety-like behaviors

Psychotropic effects of Lactobacillus plantarum PS128 in early life-stressed and naïve adult mice

Lowered anxiety- and depression-like behaviors, regulated related dopamine and serotonin

Digestive and Immune Function

Lactobacillus plantarum PS128 Ameliorated Visceral Hypersensitivity in Rats Through the Gut-Brain Axis

Ameliorated gastrointestinal symptoms

Lactobacillus plantarum PS128 Promotes Intestinal Motility, Mucin Production, and Serotonin Signaling in Mice

Increased digestive activity and immune protection

Safety

Toxicity Studies of Lactobacillus plantarum PS128™ Isolated from Spontaneously Fermented Mustard Greens

Confirmed safe and non-toxic

L. paracasei PS23

Preclinical Studies

Aging (Muscle and Brain)

Lactobacillus paracasei  PS23 dietary supplementation alleviates muscle aging via ghrelin stimulation in d-galactose-induced aging mice

Alleviated muscle atrophy that resulted from aging

Lactobacillus paracasei  PS23 decelerated age-related muscle loss by ensuring mitochondrial function in SAMP8 mice

Ameliorated age-related loss of mitochondrial function, muscle mass, and strength

Lactobacillus paracasei PS23 Delays Progression of Age-Related Cognitive Decline in Senescence Accelerated Mouse Prone 8 (SAMP8) Mice

Lessened cognitive, behavioral, and physiological signs of aging

Lactobacillus paracasei PS23 Effectively Modulates Gut Microbiota Composition and Improves Gastrointestinal Function in Aged SAMP8 Mice

Improved gut microbiota composition and GI function related to cognitive and muscle loss

Mental Health

Lactobacillus paracasei  PS23 reduced early-life stress abnormalities in maternal separation mouse model

Diminished anxiety- and depression-like symptoms, stress hormones, and inflammation

Antidepressant-like activities of live and heat-killed Lactobacillus paracasei PS23 in chronic corticosterone-treated mice and possible mechanisms

Raised BDNF levels, reduced depression- and anxiety-like behaviors and stress hormone

Digestive Health

Lactobacillus paracasei PS23 Effectively Modulates Gut Microbiota Composition and Improves Gastrointestinal Function in Aged SAMP8 Mice

Improved gut microbiota composition and GI function

Coculture Strategy for Developing Lactobacillus paracasei PS23 Fermented Milk with Anti-Colitis Effect

Strengthened intestinal epithelial barrier and showed anti-colitis benefits